Goserelin

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CAS number: 
65807-05-5 (net)
145781-92-6 (acetate)

Sequence
Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NH-NH-CO-NH2

Molecular formula: C59H84N18O14

Molecular weight: 1269.4 a.m.u.

Fields of Application
Prostate Cancer and Breast Cancer
Endometriosis and Uterine myoma
Reproduction

Description
Goserelin is a synthetic polypeptide which acts as LH-RH (Luteinizing-hormone releasing hormone) analogue agonist. LH-RH is secreted in the hypothalamus and its release induces the secretion of LH (Luitenizing hormone) and FSH (Follicle-stimulating hormone) from the pituitary gland. These two hormones act on the ovaries and the testes and are responsible of the profertility effects of LHRH through the release of steroideal hormones. Goserelin has two mutations with respect to the original primary sequence of LH-RH.

It is used to treat a number of medical problems, which include: Cancer of the prostate in men; cancer of the breast in women if it develops before or around the time of menopause; endometriosis, a painful condition caused by extra tissue growing inside or outside of the uterus and thinning of the lining of the uterus before surgery on the uterus.

When given regularly as an implant, goserelin works daily to decrease the amount of estrogens and testosterone in the blood.

Administration:
Regular injectable form and Depot injectable form.