Setmelanotide

REQUEST QUOTATION

CAS number:
920014-72-8

Sequence
Ac-Arg-Cys(1)-D-Ala-His-D-Phe-Arg-Trp-Cys(1)-NH2

Molecular formula: C49H68N18O9S2

Molecular weight: 1117.3 a.m.u.

Fields of Application
Obesity

Description
Setmelanotide is indicated for chronic weight management in people six years and older with obesity due to three rare genetic conditions: pro-opiomelanocortin (POMC) deficiency, proprotein subtilisin/kexin type 1 (PCSK1) deficiency, and leptin receptor (LEPR) deficiency confirmed by genetic testing demonstrating variants in POMC, PCSK1, or LEPR genes considered pathogenic, likely pathogenic, or of uncertain significance. Setmelanotide is the first FDA-approved treatment for these genetic conditions.

Administration:
Regular injectable form.