Molecular formula: C171H267N51O53S2
Molecular weight: 3949.4 a.m.u.
Fields of Application
Regulation of glucose homeostasis
Diabetes (type 1 and 2)
Pramlintide is a peptide analogue of human amylin with 3 proline substitutions at positions 25, 28 and 29, with antihyperglycemic activity. By mimicking amylin, pramlintide slows gastric emptying, inhibits digestive secretions (gastric acid, pancreatic enzymes, and bile), reduces glucagon secretion, and increases satiety; all of these actions are mediated mostly by glucose-sensitive areas in the brain stem. The overall result is a decrease in blood glucose levels.
Regular injectable form.