Icatibant

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CAS number:
130308-48-4
138614-30-9 (acetate salt)

Sequence
H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH Acetate salt

Molecular formula: C59H89N19O13S

Molecular weight: 1304.5 a.m.u.

Fields of Application
Treatment of acute attacks of hereditary angioedema (HAE) in adults with C1-esterase-inhibitor deficiency

Description
Icatibant is an antagonist of the human bradykinin B2 receptor (B2R), that can be used for the treatment of hereditary angioedema (HAE). Upon administration, icatibant targets and binds to B2R, thereby preventing bradykinin from binding to the B2R. This may prevent bradykinin/B2R-mediated vasodilation, the resulting increase in vascular permeability, and the swelling, inflammation, and pain associated with HAE. This may also prevent or improve pulmonary edema not associated with HAE and improve the associated decrease in blood oxygen levels.

Administration:
Regular injectable form.