Etelcalcetide

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CAS number:
1262780-97-1

Sequence
Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2.H-Cys(1)-OH

Molecular formula: C38H73N21O10S2

Molecular weight: 1048.3 a.m.u.

Fields of Application
Secondary hyperparathyroidism in patients with chronic kidney disease (CKD) undergoing hemodialysis

Description
Etelcalcetide is a calcimimetic and calcium-sensing receptor (CaSR) agonist composed of a synthetic peptide comprised of seven D-amino acids. Etelcalcetide mimics calcium and allosterically binds to and activates the CaSR expressed by the parathyroid gland. This suppresses the synthesis and secretion of parathyroid hormone (PTH), thereby reducing PTH levels and lowering serum calcium and phosphorus levels. Elevated PTH is often observed in patients with CKD and is associated with dysregulated calcium-phosphate homeostasis.

Administration:
Injectable form.