Somatostatin

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CAS number: 
38916-34-6 (net)
38916-34-6 (acetate)

Sequence
Cyclo(3-14)Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys

Molecular formula: C76H104N18O19S2

Molecular weight: 1638 a.m.u.

Fields of Application
Gastrointestinal haemorrhage, including bleeding from oesophageal varices
Postoperative pancreatic and duodenal fistulae
Treatment of cancer has been also reported

Description
Somatostatin is a hypothalamic release-inhibiting hormone which inhibits the release of the growth hormone from the anterior pituitary. It can also be found in the stomach, thyroid, intestine, salivary glands and in the pancreas.

At the hypothalamic tract, Somatostatin regulates the secretory activity of the cellules of the anterior pituitary. In several animal species it also inhibits the release of GH and TSH without affecting the release of hormones such as FSH and ACTH.

In the Pancreas Somatostatin inhibits the endocrinal (insulin and glucagon) and esocrinal (bicarbonate, water and pancreatic enzymes) secretions, in basal conditions and as well under alimentary stimulus.

The intravenous infusion of 100 µg or more of Somatostatin induces reduced circulating concentrations of growth hormone in patients with acromegaly. It may also inhibit the release of thyrotropin and corticothropin from the pituitary.

Administration:
Regular injectable form.