Salmon calcitonin

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CAS number: 
47931-85-1

Sequence
Cyclo(1-7)Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2

Molecular formula: C145H240N44O48S2

Molecular weight: 3432 a.m.u.

Fields of Application
Osteoporosis
Hypercalcemia
Paget’s disease

Description
Calcitonin (salmon) is a hormone known to participate in calcium and phosphorous metabolism. Calcitonin is a 32 amino acid peptide, cleaved from a larger prohormone. It contains a single disulfide bond.

Calcitonin lowers the calcium concentration in plasma of mammals by diminishing the rate of bone resorption. It prevents the release of calcium and phosphorous into blood by inhibiting the osteoclasts, a cell type that “digests” bone matrix. It is obtained by chemical synthesis and is available in acetate form.

Calcitonins are used to treat severe hypercalcemia of various origins, Paget’s disease, osteoporosis of various origins, and intractable cancer pain in patients with malignant bone metastases.

Administration:
Regular injectable form and Nasal Spray.

Calcitonina