Octreotide

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CAS number: 
83150-76-9 (net)
79517-01-4 (acetate)

Sequence
Cyclo(2-7)D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Throl

Molecular formula: C49H66N10O10S2

Molecular weight: 1019.3 a.m.u.

Fields of Application
Acromegaly
Carcinoid Syndrome
Gastrointestinal haemorrhage

Description
Octreotide is a Somatostatin analogue which has increased biodisponibility due to the presence of a residue of D-Phe at the N-terminus and a residue of threoninol at the C-terminus which makes it more resistant to body enzymes. Since its discovery in 1980 it has proved to inhibit Growth Hormone and inhibit also in part glucagon and insulin. However, this peptide is quite selective in inhibiting the secretion of GH without affecting severely the levels of insulin and glucagon in blood.

Octreotide is used to treat the severe diarrhoea and other symptoms that occur with certain intestinal tumours.

It is also used to treat a condition called acromegaly, which is caused by excessive levels of growth hormone in the body. Octreotide works by reducing the amount of growth hormone that the body produces.

Administration:
Regular injectable form and Depot injectable form.

Octreotide