Gonadorelin

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CAS number: 
33515-09-2 (net)
52699-48-6 (acetate)

Sequence
Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Molecular formula: C55H75N17O13

Molecular weight: 1181.6 a.m.u.

Fields of Application
Reproduction.
Diagnosis of hypothalamic-pituitary-gonadal function
Veterinary:  Reproduction
Ovarian cysts

Description

Gonadorelin or gonadotropin-releasing hormone (LHRH, also known as GnRH) is a ten amino acid peptide that is synthesized and secreted from hypothalamic neurons and binds to receptors on gonadotrophs.

Gonadorelin causes the pituitary gland to release other hormones (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]). LH and FSH control development in children and fertility in adults. In both sexes LH stimulates secretion of sex steroids from the gonads. LH binds to receptors on Leydig cells, in the testes stimulating synthesis and secretion of testosterone, and in the ovary stimulating secretion of estrogens.

Gonadorelin is used to test how well the hypothalamus and the pituitary glands are working. It is also used to cause ovulation (release of an egg from the ovary) in women who do not have regular ovulation and menstrual periods because the hypothalamus gland does not release enough LHRH.

Administration:
Regular injectable form.