Elcatonin

REQUEST QUOTATION

CAS number: 
60731-46-6

Sequence
Cyclo(-Ser-Asn-Leu-Ser-Thr-Asu)-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-NH2

Molecular formula: C148H244N42O47

Molecular weight: 3363 a.m.u.

Fields of Application
Osteoporosis
Hypercalcemia
Paget’s disease

Description
Elcalcitonin is a synthetic polypeptide analogue of salmon calcitonin I. It lowers the calcium concentration in plasma of mammals by diminishing the rate of bone resorption. It prevents the release of calcium and phosphorous into blood by inhibiting the osteoclasts, a cell type that “digests” bone matrix.

It is obtained by chemical synthesis and it is available as acetate.

Calcitonins are used to treat severe hypercalcemia of various origins, Paget’s disease, osteoporosis of various origins, and intractable cancer pain in patients with malignant bone metastases.

Administration:
Nasal Spray.