Molecular formula: C46H64N14O12S2
Molecular weight: 1069.24 a.m.u.
Fields of Application
Central diabetes insipidus, polyuria, polydipsia
Mild and moderate forms of hemophilia A and von Willebrand disease
Desmopressin is a synthetic analogue of Vasopressin which is a well known neurohypophyseal antidiuretic hormone. Vasopressin can be found in the mammalian kidney where it regulates water reabsorption in the collecting tubules and salt transport. The substitution of the amino terminal Cys residue by mercaptopropanoic acid together with the change in configuration in Arg8, confer to desmopressin an enhanced antidiuretic efficacy and a reduced pressor potency compared with those of vasopressin.
Desmopressin is taken through the nose, by mouth, or given by injection to prevent or control the frequent urination, increased thirst, and loss of water associated with diabetes insipidus (water diabetes).
It is used also to control bed-wetting and frequent urination and increased thirst associated with certain types of brain injuries or brain surgery. Desmopressin works by acting on the kidneys to reduce the flow of urine.
Desmopressin is also given by injection to treat some patients with certain bleeding problems such as hemophilia or von Willebrand’s disease.
Regular injectable form, Nasal spray and Oral tablets.