Buserelin

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CAS number: 
57982-77-1 (net)
68630-75-1 (acetate)

Sequence
Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NH-CH2-CH3

Molecular formula: C60H86N16O13

Molecular weight: 1239.5 a.m.u.

Fields of Application
Prostate Cancer and Endometriosis
Uterine fibroids
Reproduction
Precocious central puberty
Veterinary: Induction of ovulation (cows, mares and rabbits)
Treatment of ovarian disorders

Description
Buserelin is a synthetic nonapeptide analogue of human Gonatropin-releasing hormone (LH-RH) with agonistic activity to gonadorelin.

It is used to treat cancer of the prostate gland. Intranasal and subcutaneous buserelin have demonstrated efficacy in a variety of conditions, including endometriosis, uterine leiomyoma, advanced prostate cancer, polycystic ovary syndrome, central precocious puberty. It has also enhanced success rates of in-vitro fertilization programs. However, comparative trials with other LH-RH analogs (e.g. leuprolide, goserelin) are necessary to establish the place in therapy of buserelin.

Administration:
Regular injectable form and Nasal spray.