Alarelin

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CAS number: 
52435-06-0 (net)
79561-22-1 (acetate)

Sequence
Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHCH2CH3

Molecular formula: C56H78N16O12

Molecular weight: 1167.35 a.m.u.

Fields of Application
Veterinary: Several activities have been described, like induction of ovulation.

Description
Alarelin is a synthetic polypeptide which acts as LH-RH (Luteinizing-hormone releasing hormone) analogue agonist. LH-RH is secreted in the hypothalamus and its release induces the secretion of LH (Luitenizing hormone) and FSH (Follicle-stimulating hormone) from the pituitary gland. These two hormones act on the ovaries and the testes and are responsible of the profertility effects of LHRH through the release of steroideal hormones.

The biological activity of Alarelin, a synthetic LH-RH agonist, is dozens of times higher than that of LH-RH in the test of rat hypophyseal stimulation of gonadotropin secretion in vivo and in vitro and in the ovulation induction test.

Administration:
Regular injectable form.